In vitro labelling and detection of mesenchymal stromal cells: a comparison study

Is it possible to label, without altering cell viability, rat bone marrow mesenchymal stromal cells with superparamagnetic iron oxide nanoparticles and perfluorocarbon nanuemulsion formulations?

Key points:

• SPIO-labelled cells are viable and MRI-detectable at all dilutions tested

• PFC-labelled cells are viable and MRS-detectable if >0.5 x 10^6

• Detection of MSCs might consider multimodal approaches including SPIO and PFC compounds

Article: In vitro labelling and detection of mesenchymal stromal cells: a comparison between magnetic resonance imaging of iron-labelled cells and magnetic resonance spectroscopy of fluorine-labelled cells

Authors: Stefania Rizzo, Francesco Petrella, Ileana Zucca et al.